Use Caution/Monitor. Avoid or Use Alternate Drug. FERAHEME Dosing & Administration - Feraheme By clicking send, you acknowledge that you have permission to email the recipient with this information. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Iron Deficiency Calculator (3) Known hypersensitivity to Venofer. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. This drug is available at a higher level co-pay. IV iron products (adults) - UpToDate Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Applies only to oral form of both agents. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer Dosing and Administration Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Please confirm that you would like to log out of Medscape. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Applies only to oral form of both agents. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. 1. Human studies not conducted. The iron formulation choice remains for the clinician to make. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. 1982;13(4):309-21. Applies only to oral form of both agents. Monitor Closely (1)didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Applies only to oral form of both agents. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Use Caution/Monitor. Separate dosing of tetracyclines from these products. Applies only to oral form of both agents. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Use Caution/Monitor. Minor/Significance Unknown. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Applies only to oral form of both agents. Schweiz Med Wochenschr. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Applies only to oral form of both agents. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Creating an account is free and takes less than 1 minute. PDF Treatment Guideline - Gloucestershire Royal Hospital Observed Hb = the patients current hemoglobin in g/dl. Compare formulary status to other drugs in the same class. If either is present, do not use the liquid. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. All Rights Reserved. commonly, these are generic drugs. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Below the form there are further instructions on how to use the calculator. Modify Therapy/Monitor Closely. The above information is provided for general iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. Applies only to oral form of both agents. Ren Fail. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Use Caution/Monitor. Use Caution/Monitor. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Parenteral iron dextran therapy: a review. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Steps on how to print your input & results: 1. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Consult your doctor before breast-feeding. . Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Deferoxamine chelates iron. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Applies only to oral form of both agents. Consult your pharmacist or local waste disposal company. Fulminant symptoms may include general paleness, confusion or episodes of passing out. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Minor/Significance Unknown. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Separate dosing of tetracyclines from these products. This site complies with the HONcode standard for trust- worthy health information: verify here. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. 1. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Intravenous iron sucrose: establishing a safe dose. Formula for calculating the required dose of iron sucrose 1. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Test Dose: Not required. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Either decreases levels of the other by inhibition of GI absorption. Minor (1)iron sucrose, captopril. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Ganzoni Equation for Iron Deficiency Anemia - MDCalc Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. This cost includes the fee charged by the pharmacy. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Chandler G, Harchowel J, Macdougall I. Dosing and Infusion Rates - PRIVIGEN In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Most pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Ganzoni AM. Avoid or Use Alternate Drug. Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Iron Deficiency Calculator - MDApp Applies only to oral form of both agents. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . David McAuley, Pharm.D. Avoid or Use Alternate Drug. iron sucrose, benazepril. Avoid or Use Alternate Drug. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Use Caution/Monitor. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Applies only to oral form of both agents. Administer a test INFeD dose prior to the first therapeutic dose. If you log out, you will be required to enter your username and password the next time you visit. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. May increase risk of hypotension. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Before using, check this product visually for particles or discoloration. Applies only to oral form of both agents. Use Caution/Monitor. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Anemia; 2015: 763576. Applies only to oral form of both agents. This site complies with the HONcode standard for trust- worthy health information: verify here. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. 2010;18(3). 3. 5. Access your plan list on any device mobile or desktop. Applies only to oral form of both agents. Interaction only with oral iron administration. Each mL contains 20 mg of elemental iron. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. Recommended dosing and infusion rates for PI. IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). 1) Ganzoni AM. We have found the lower dose to be better tolerated in the second half of gestation. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Med J Aust. Use Caution/Monitor. 1996 Aug;11(4):139-46. Intravenous iron therapy for patients with anemia David McAuley, Pharm.D. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Deferasirox chelates iron. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Either increases effects of the other by pharmacodynamic synergism. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Slow or stop the infusion if adverse reactions occur. iron sucrose decreases levels of manganese by inhibition of GI absorption. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. Dosage Calculator - [100% Free] - Calculators.io Venofer treatment may be repeated if necessary. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Parenteral iron supplementation. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Administer Venofer only intravenously by slow injection or by infusion. DailyMed - VENOFER- iron sucrose injection, solution didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. You may need extra iron because of blood loss during kidney dialysis. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Modify Therapy/Monitor Closely. Applies only to oral form of both agents. dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. trientine, iron sucrose. Deferoxamine chelates iron. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. 4. Applies only to oral form of both agents. Contact the applicable plan Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. World J Gastroenterol; 16(22): 27202725. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. You may report side effects to Health Canada at 1-866-234-2345. Minor/Significance Unknown. This information is not individual medical advice and does not substitute for the advice of your health care professional. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Use Caution/Monitor. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Applies only to oral form of both agents. Generic name: IRON SUCROSE 20mg in 1mL Your list will be saved and can be edited at any time. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Corrected Calcium. Shirley, NY: American Regent, Inc.; 9/2020. Copyright 1993-2021 Applies only to oral form of both agents. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. Applies only to oral form of both agents. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. FERAHEME vs Venofer (iron sucrose) - Feraheme Venofer treatment may be repeated if iron deficiency reoccurs. For liquid medications, also enter the value of the Medicine Concentration and choose . iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Ferrlecit may be diluted in 100 mL of 0.9% sodium chloride administered by intravenous infusion over 1 hour per dialysis session. Minor/Significance Unknown. Avoid or Use Alternate Drug. UpToDate. Avoid or Use Alternate Drug. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Use Caution/Monitor. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Applies only to oral form of both agents. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Feraheme does not contain antimicrobial preservatives. Interaction only with oral iron administration. 1970; 100(7):301-3. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Intravenous iron sucrose for children with iron deficiency anemia: a Kumpf VJ, Holland EG. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Dose. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Parenteral Iron Replacement For Anemia Calculator - MDApp Otherwise, call a poison control center right away. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. This website also contains material copyrighted by 3rd parties. PDF Injectafer (ferric carboxymaltose injection) - Food and Drug Administration Applies only to oral form of both agents. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Avoid or Use Alternate Drug. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Applies only to oral form of both agents. Monofer 100mg/ml solution for injection/infusion - Summary of Product Use alternatives if available. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Corrected Sodium and Effective Osmolality. One dose IV Iron replacement | Monoferric Do not double the dose to catch up. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. 1970;100(7):301303. Use Caution/Monitor. No data are available regarding overdosage of Venofer in humans. Crown Rump Length and Nuchal Translucency. Minor/Significance Unknown.